Daniel Dairaghi, Ph.D., Director, Molecular Pharmacology of ChemoCentryx, in a announcement demonstration termed “A Novel CCR1Antagonist CCX354-C for Rheumatoid Arthritis” in Rome, Italy, at the annual European Congress of Rheumatology (EULAR), announced positive Phase 1 outcomes for its new drug competitor CCX354. CCX354 is an oral activated tiny molecule drug competitor devised especially to aim the CCR1 chemokine receptor to treat patients with rheumatoid arthritis (RA). Facts indicated that CCX354 was safe and very acceptable with a clear pharmacokinetic to pharmacodynamic alliance.
The studies findings displayed that CCX354 was well accepted and showed linear dose exposure profile in single and multiple dose Phase 1 studies in healthy volunteers. Plasma levels greatly surpassed the requirement for acceptable receptor blockade. High amounts of receptor coverage at a 12 hour time check were accomplished after one dose of 100 mg CCX354.
The details and information from other labs also present that a large degree of CCR1 receptor coverage is vital to attain a therapeutic reaction in inflammatory diseases like RA, according to Thomas J. Schall, Ph.D., President and Chief Executive Officer of ChemoCentryx. He went on to acknowledge that they are immensely satisfied that the study displayed rare ability of CCX354 to discern and appropriately block the CCR1 receptor objectives that other molecules in this grouping have been incapable to accomplish as of yet. They believe that the CCR1 antagonist is the best available in this grouping to possibly provide a medication to treat patients with RA.
CCX354 is extremely powerful and particular antagonist of CCR1, a chemokine receptor that expedites the exertion of inflammatory monocytes and macrophages into the joints of RA patients and restraining the inflammation, swelling, pain and linked joint loss while decreasing the possibility for off target events, while providing a larger therapeutic outlet the the approved therapies that are now in use.
Rheumatoid Arthritis and CCX354
Rheumatoid arthritis (RA) is a continuous incapacitating inflammatory disease that induces pain, stiffness, swelling and places limits on motion and function of several joints. Estimations in the United States indicate that two million persons have this disease and it is one of the main causes of morbidity and work disability. What exactly causes this disease is not yet known, but it is conceived that it repeats the bodies immune system attack on the tissues lining the joints. Even with treatment options improving, there still is no cure or one type of therapy that is useful for all RA patients. Treatment of RA is divided into Disease Modifying Antirheumatic Drugs (DMARDs), anti inflammatory agents and analgesics. Creating a $10 billion market.
ChemoCentryx are also the creators of CCR9 a drug for Crohn’s Disease which shows in effective therapeutic values in later progression stages of the disease. They also have CCR2 for Type 2 Diabetes and is linked to inflammatory diseases including anthersclerosis and metabolic syndrome.
Treatments for RA include a variety of techniques and is geared at decreasing pain, joint swelling and slowing down or preventing damage to the joints along with improvement of physical ability and overall well being.
Conventional medicine includes anti inflammatory drugs (NASIDs) such as Nuprin and Celebrex. Nuprin’s list of side effects include nausea, vomiting, headaches along with serious ones like stomach pain and swelling of hands and feet. Celebrex can cause life threatening heart or circulation problems and can also seriously effect your stomach and intestines.
Anti rheumatic drugs (DMARD’s) such as Neoral that can make person more sensitive to infections and decreases the bodies immune system to fight off illness, can cause high blood pressure and kidney infections.
Corticosteroids such as perdnisone which can cause severe allergic reactions, convulsions and depression to name a few.
Natural therapies are more and more popular today for Ra. Natural therapies gives you more control in your health and healing, more pain control and increased activity levels.
Some of the therapies used are as follows:
Mind and Body Therapy
Mind and body therapy can help reduce the stress from the disease, improve sleep and pain awareness.
Acupuncture decreases pain levels by setting off pain blocking chemicals (endorphins), the bodies natural pain killers. Acupuncture in studies has shown to improve pain in RA patients.
Massage therapy can help reduce pain and decrees stress levels.
The American Chiropractic Association advises chiropractic care for RA patients to help improve range of motion, flexibility, endurance, muscle strengthening and toning.
Some local alternative practitioners in St. Louis:
The Center for mind, body and spirit
7649 Delmar Boulevard
Indiog Massage and Wellness Therapy
Natural Life Therapy Clinic
443 N. New Ballas Road
A Better Life Wellness Center
11029 Manchester Road
Triad Sports and Family Chiropractic
22 N. Sarah Street
McIntyre Chiropractic & Acupuncture Centre
1415 Big Bend Boulevard